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Biotechnology and animal reproduction
The Center of Animal Reproduction in Vairão (CRAV) is the result of an investment of the University of Porto as part of the veterinary campus of the Abel Salazar Biomedical Institute (ICBAS). At the center, veterinary services in the area of Animal Reproduction (Theriogenology) are provided, with emphasis in equine assisted reproduction and in vitro fertilization of bovine oocytes. The facilities are designed to accommodate stallions and mares, with or without foals, either in boxes or paddocks. The laboratories are fully equipped to provide routine and specialized services, in the area of animal reproduction.
Experimental Surgery and Regenerative Medicine
Veterinary cell therapy service:
Joint diseases are a common occurrence in pets, particularly in dogs, and can be highly debilitating and affect the animal's quality of life. Although there are currently several options for approaching these pathologies, from medical to surgical treatment, in many cases the clinical evolution is not favorable and the results are below expectations.
Cellular therapies are a promise in the treatment of osteochondrodegenerative diseases due to their ability to migrate to injury sites, the possibility of undergoing chondrogenic differentiation and paracrine and immunomodulatory actions. In addition, treatments that use cell applications have shown a particularly interesting action due to the secretion of mediators that promote joint regeneration, stimulating the proliferation of progenitor cells and inhibiting apoptosis and joint degeneration. In summary, these cells promote joint protection and regeneration.
2. Pre-clinical testing service for the development of cell and biomaterial therapies - Cytocompatibility and Biocompatibility Tests
The Cytocompatibility and Biocompatibility Tests are essential tools in determining the safety associated with the use of a given biomaterial for regenerative therapies in different tissues. Following the standards imposed by ISO 10993-6: 2016, in a first stage the different types of cells are grown in contact with the Biomaterial to be tested in order to determine the positive or negative influences that this association may have on the levels of cell viability and your metabolic performance.
Subsequently, and proving good results of cytocompatibility, the same biomaterials are subjected to biocompatibility tests, in which they are applied subcutaneously in animal models of increasing complexity (rat and sheep), and in which they will be collected in specific timepoints to determine the presence of local reaction phenomena (foreign body reactions, fibrosis and inflammatory reactions) and / or systemic (inflammatory reactions or signs of organic rejection in visceral organs).
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