PUBLICATIONS

Helminth infection-induced malignancy is a major field of research in this CECA thematic line and supported by a strong international collaboration team that includes George Washington University, USA, Khon Kaen University, Thailand, Siberian State Medical University and Novosibirsk University, Russian Federation. Researchers implicated in this thematic line integrate the Tomsk Opisthorchiasis Consortium (TOPIC). This close collaboration has given rise to several scientific articles.

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• Gouveia MJ, Brindley PJ, Rinaldi G, Gärtner F, Costa JMC, Vale N. Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts. Infect Agent Cancer 2019, 14, 41.

• Gouveia MJ, Brindley PJ, Rinaldi G, Gärtner F, Correia da Costa JM, Vale N. Combination anthelmintic/antioxidant activity against . Biomolecules 2019, 9, 54.

• Gouveia MJ, Brindley PJ, Azevedo C, Gärtner F, da Costa JMC, Vale N. The antioxidants resveratrol and -acetylcysteine enhance anthelminthic activity of praziquantel and artesunate against Schistosoma mansoni. Parasite & Vectors, 2019 12, 309.

• Gouveia MJ, Brindley PJ, Gärtner F, Correia da Costa JM, Vale N. Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules. Pharmaceuticals 2018, 11, 15.

• Gouveia MJ, Pakharukova MY, Laha T, Sripa B, Maksimova G, Rinaldi G, Brindley PJ, Mordvinov VA, Amaro T, Santos LL, Correia da Costa JM and Vale N. Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model. Carcinogenesis 2017, 38, 929.

• Bernardo C, Cunha MC, Santos JH, Correia da Costa JM, Brindley PJ, Lopes C, Amado F, Ferreira R, Vitorino R, Santos LL. Insight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomics. Tumor Biology 2016, 37(8):11279-11287.

• Brindley PJ, Correia da Costa JM and Sripa B. Why Does Infection With Some Helminths Cause Cancer? Trends in Cancer 2015, 1, 174.

• Gouveia MJ, Santos J, Brindley PJ, Rinaldi G, Lopes C, Santos LL, Correia da Costa JM, Vale N. Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer. Cancer Letters 2015, 359, 226-232.

• Correia da Costa JM, Vale N, Gouveia MJ, Botelho MC, Sripa B, Santos LL, Santos JH, Rinaldi G, and Brindley PJ. Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers. Front Genet 2014, 5, 444.

• Botelho MC, Vale N, Gouveia MJ, Rinaldi G, Santos J, Santos LL, Gomes P, Brindley PJ, Correia da Costa JM. Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: An oestrogen–DNA adducts mediated pathway? International Journal for Parasitology 2013, 43, 17–26.

• Vale N, Gouveia MJ, Botelho M, Sripa B, Suttiprapa S, Rinaldi G, Gomes P, Brindley PJ, Correia da Costa JM. Carcinogenic liver fluke Opisthorchis viverrini oxysterols detected by LC–MS/MS survey of soluble fraction parasite extract. Parasitology International 2013, 62, 535–542